Plant secondary metabolites for the prevention and treatment of colorectal cancer: A review

Colorectal cancer is becoming more common and deadly in both men women nowadays. Although various treatment interventions are available including chemotherapy, surgery, radiation therapy hormonal therapy, they associated with some harmful effects. To avoid the risk factors these therapies, natural products could be used as one of most promising candidates for colorectal cancer. The their dietary supplements demonstrated stronger potential against cells. Flavonoids, phenolics, terpenoids, saponins, quinones, alkaloids, other secondary metabolites among bioactive substances found supplements. These phytochemicals exhibited strong potent cytotoxicity cells which indicated ability chemopreventive agents. Both intrinsic extrinsic routes were to trigger apoptosis by phytochemical substances. Phytochemicals influenced cell cycle regulation, oncogenes, tumor markers induced modulating tumor-suppressive miRNAs, affecting signaling pathways, upregulating apoptotic inducers downregulation anti-apoptotic proteins factors. Thus, this review, we addressed sources mechanism isolated anti-colorectal